At least 2 players, an episode or two of the TV show Lost, and as many drinks as necessary.
Everyone needs to be in view of the TV and they need to have their drinks to hand.
Playing the Lost drinking game is incredibly simple. All you need to do is watch the show and every time one of the situations below happens, take a drink. The situations are as follows:
There’s a reference to numbers
Hurley says “Dude”
A new Dharma station is revealed
Desmond says “Brother”
A pre-crash connection is revealed between characters
Sawyer grimaces or furrows his brow
There’s a flashback
There’s a flash forward
Someone pulls a gun
Sawyer calls someone by a nickname
Charlie mentions Driveshaft
Jack makes a mild threat
Kate’s torn between Jack and Sawyer
Jin says something far too complicated for someone new to speaking English
A character turns out to be an “other”
Ominous music starts to play
Someone says “It’s complicated”
Locke goes/does something crazy
Ben says something menacing
Sayid takes charge
If you know the show well you can tailor your episode choice depending on how much or little you want to drink.
Of course, there are countless other situations that you can add to the list, and some situations will be more appropriate to certain seasons than others. See if you can add your own and tailor them to your season choice.